Prime Mixed-Use Property with Waterviews in Historic South End, Portsmouth, NH. Welcome to a unique investment opportunity in the heart of Portsmouth's charming South End! This 2-story property boasts a perfect blend of commercial and residential spaces, making it an ideal choice for entrepreneurs and investors alike. Situated next door to Sanders Fish Market, this property is at the epicenter of South End's vibrant community. Enjoy the convenience of being steps away from the bustling Farmer's Market, Prescott Park, historic Strawbery Banke, and all the cultural and culinary delights Portsmouth and the Seacoast have to offer. The ground level features a versatile commercial shop space, perfect for retail, food service, a boutique, or an office. With high foot traffic and excellent visibility, your business will thrive in this prime location. The second story hosts a charming 1-bedroom apartment with water views of the picturesque Piscataqua River, an ideal location perfect for an owner-occupant or as a desirable rental unit. This property seamlessly blends historic character with modern amenities. The South End's historic appeal, combined with the property's well-positioned corner location, ensures a unique opportunity to be a neighborhood hot spot. From dining and shopping to parks and waterfront activities, everything you need is within walking distance. The vibrant community and lively atmosphere make this location highly sought after. PRE-INSPECTED. Shown By Appointment.